The most annoying thing about working in an office again:

No mid-day purr breaks for stress relief. In the almost-a-year I have had him, The Big Cat In The City has become quite the lap cat, always there on my desk for a quick purr session when desired.

The second most annoying thing about working in an office again:

The need to own some presentable clothes and launder them often enough to keep them presentable.

The best thing about it:

Having the opportunity to meet new people. I even got a date just from standing on line at the Starbucks across the street, which is the kind of interaction you don't get when your office is in your garage, you're wearing ancient jeans and have a cat on your lap.